This is something that I am constantly trying to do and accomplish. It is hard, but when I achieve a zero inbox I find I am more productive and responsive.
Merlin Mann just did a presentation at Google and discussed getting to “Inbox Zero”. It is an interesting talk and perfect for those who study and need a refresher on “Getting Things Done” or as we know it, GTD.
http://video.google.com/googleplayer.swf?docId=973149761529535925&hl=en
Mile High Soapbox 